Structure-guided drug development for treatment of rifampin-resistant TB

X-ray crystallographic study of the mechanism of transcription

Cryo-EM to capture structures of macromoles in transcription process

X-ray crystal structure of RNA polymerase and DksA/ppGpp complex

Bacteriophage N4 RNA polymerase

Welcome to the Murakami Lab at Penn State University

Our research interests are centered on understanding the mechanism of gene expression by the enzyme RNA polymerase. We apply X-ray crystallography and cryo-electron microscopy techniques to reveal three-dimensional structures of bacterial, archaeal and bacteriophage RNA polymerases for elucidating the mechanism of RNA transcription and its regulation.

Open Positions (Postdoc, Graduate and Undergraduate students)

Latest news:

December 18, 2020: A manuscript reporting the structure and function of HelD, RNA polymerase binding ATP-dependent helicase is published. URee Chon, a former undergrad in my lab determined the X-ray crystal structure of a part of HelD.

November 30, 2020: A manuscript reporting the structure and function of archaeal general transcription factor TFEα is published.

November 25, 2020: Katsu Murakami named a fellow of the American Association for the Advancement of Science (AAAS).

June 9, 2020: Yeonoh Shin presented a poster at the CHESS Users’ meeting and won a poster award. Congratulations!

May 9, 2020: Yeonoh Shin and Catherine Sutherland graduated Penn State BMMB program. Congratulations!

May 6, 2020: A manuscript reporting structural basis of ribosomal RNA transcription regulation is submitted. BioRxiv

March 1, 2020: Rishi Vishwakarma joined the Murakami and Babitzke’s labs as a research assistant professor. Welcome to Penn State!

Feb 21, 2020: Yeonoh passed his Ph. D. thesis defense. Congratulations!