HOME2018-09-25T14:26:04+00:00

Structure-guided drug development for treatment of rifampin-resistant TB

X-ray crystallographic study of the mechanism of transcription

Cryo-EM to capture structures of macromoles in transcription process

X-ray crystal structure of RNA polymerase and DksA/ppGpp complex

Bacteriophage N4 RNA polymerase

Welcome to the Murakami Lab at Penn State University

Our research interests are centered on understanding the mechanism of gene expression by the enzyme RNA polymerase. We apply X-ray crystallography and cryo-electron microscopy techniques to reveal three-dimensional structures of bacterial, archaeal and bacteriophage RNA polymerases for elucidating the mechanism of RNA transcription and its regulation.

Latest news:

Sept 20, 2018: A paper reporting the mechanism of action of kanglemycin A, a naturally occurring antibiotic active against drug-resistant tuberculosis, is published in Molecular Cell. Congratulations Vadim and Yeonoh. More…

August 14, 2018: A review paper for introducing the structure and function of E. coli RNA polymerase is published in EcoSal Plus.

July 10, 2018: A paper reporting the crystal structures of the N4 phage RNA polymerase II is published in J. Biol. Chem.

March 28, 2018: A paper reporting the Cryo-EM structure of E. coli RNA polymerase open complex is published in J. Biol. Chem.

February 22, 2018: A paper reporting the crystal structure of E. coli RNA polymerase and DksA/ppGpp complex is published in Molecular Cell. Congratulations Vadim! More…